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Comparison of frozen and freeze-dried particulate bone allografts.

Malinin T, Temple HT

Tissue Bank, Department of Orthopaedics (R-12), University of Miami, Miller School of Medicine, Miami, FL 33101, USA. tmalinin@med.miami.edu

Freeze-dried and frozen particulate bone allografts are used interchangeably on the assumption that the biologic behavior of these grafts is similar. Dissimilarities in biologic behavior and differences in the rate and extent of bone incorporation of freeze-dried and frozen particulate grafts were demonstrated in a comparative study using a non-human primate model. Freeze-dried particulate allografts induced new bone formation and healing of the osseous defects much faster than the frozen allografts.

Published 3 September 2007 in Cryobiology, 55(2): 167-70.
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