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The effect of dendritic cells on the retinal cell transplantation.

Oishi A, Nagai T, Mandai M, Takahashi M, Yoshimura N

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Japan.

The potential of bone marrow cell-derived immature dendritic cells (myeloid iDCs) in modulating the efficacy of retinal cell transplantation therapy was investigated. (1) In vitro, myeloid iDCs but not BMCs enhanced the survival and proliferation of embryonic retinal cells, and the expression of various neurotrophic factors by myeloid iDCs was confirmed with RT-PCR. (2) In subretinal transplantation, neonatal retinal cells co-transplanted with myeloid iDCs showed higher survival rate compared to those transplanted without myeloid iDCs. (3) CD8 T-cells reactive against donor retinal cells were significantly increased in the mice with transplantation of retinal cells alone. These results suggested the beneficial effects of the use of myeloid iDCs in retinal cell transplantation therapy.

Published 4 October 2007 in Biochem Biophys Res Commun, 363(2): 292-6.
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