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Mesenchymal stem cellular adhesion and cytotoxicity study of random biopolyester scaffolds for tissue engineering.

Tang XJ, Wu QY

Department of Cardiac Surgery, Cardiovascular Institute and Fu Wai Hospital, CAMS and PUMC, 100037, Beijing, Peoples Republic of China, hkcytangxiujie@sina.com.

Mesenchymal stem cells (MSCs) were isolated from the bone marrow of rabbits and inoculated respectively on 3D scaffolds of poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) (PHBV), poly(butylenes succinate) (PBS) and different blends (100/0, 80/20, 50/50, 20/80, 0/100) (Wt%) in vitro. It was found that the (50/50) blends possessed the best performance on adhesion and cytotoxicity of MSCs. The scanning electronic microscopy (SEM) results showed that the (50/50) blends had the appropriate roughness for MSCs to attach and grow, which may be used as a suitable biomaterial to create small caliber vascular grafts.

Published 13 June 2006 in J Mater Sci Mater Med, 17(7): 627-32.
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