Bone Grafts Research Today is a free monthly online journal that collates and summarizes the latest research about Bone Grafts, including details on spine fusion, surgery, procedure, risks.

The effect of platelet-enriched fibrin glue on bone regeneration in autogenous bone grafts.

Huh JY, Choi BH, Zhu SJ, Jung JH, Kim BY, Lee SH

Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea.

OBJECTIVE: The aim of this study was to examine the ability of platelet-enriched fibrin glue to enhance bone formation in critically sized defects in the dog mandible. STUDY DESIGN: Seven adult female mongrel dogs underwent continuity resections on both sides of the mandible; 1 defect was reconstructed with the original particulate bone mixed with platelet-enriched fibrin glue, and as a control the contralateral defect was reconstructed with the original particulate bone alone. RESULTS: Biopsies after 6 weeks showed that the addition of platelet-enriched fibrin glue enhanced new bone formation in the autogenous bone grafts. CONCLUSION: Our data suggest that fibrin nets formed by fibrinogen, in combination with growth factors present in platelet-enriched fibrin glue, might effectively promote bone healing at bone graft sites.

Published 20 March 2006 in Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 101(4): 426-31.
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