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Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells.

Kawamura H, Yagita H, Nisizawa T, Izumi N, Miyaji C, Vance RE, Raulet DH, Okumura K, Abo T

Department of Immunology, Niigata University School of Medicine, Niigata, Japan. h-kawa@med.niigata-u.ac.jp

Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic bone marrow transplantation, which is caused by donor T cells specific for host alloantigens. In a murine model, we found that donor T cells expressed a natural killer cell inhibitory receptor, CD94/NKG2A, during the course of aGVHD. Administration of an anti-NKG2A mAb markedly inhibited the expansion of donor T cells and ameliorated the aGVHD pathologies. These results suggested that the CD94/NKG2A inhibitory receptor expressed on host-reactive donor T cells can be a novel target for the amelioration of aGVHD.

Published 15 August 2005 in Eur J Immunol, 35(8): 2358-66.
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