Bone Grafts Research Today is a free monthly online journal that collates and summarizes the latest research about Bone Grafts, including details on spine fusion, surgery, procedure, risks.

Total mandibular reconstruction for massive osteolysis of the mandible (Gorham-Stout syndrome).

Paley MD, Lloyd CJ, Penfold CN

Department of Oral and Maxillofacial Surgery, Glan Clwyd Hospital, Bodelwyddan, Rhyl, North Wales LL18 5UJ, UK. martin@paley10.freeserve.co.uk

Massive osteolysis (Gorham-Stout syndrome) is a rare condition of unknown aetiology that is thought to result from a localised endothelial proliferation of lymphatic vessels resulting in destruction and absorption of bone. The diagnosis of Gorham-Stout syndrome can be made only after first excluding osteolysis from infection, inflammation, endocrine disease, and cancer. The syndrome is rarely seen in the facial skeleton and has a variable prognosis. Many treatments have been advocated but only surgery and radiotherapy have had some success. We present a case of massive osteolysis of the entire mandible, which was reconstructed with a free vascularised fibular graft and bilateral prosthetic replacements of the temporomandibular (TMJ) joints. Four years later the fibular graft had been absorbed requiring further reconstruction with another fibula graft.

Published 7 March 2005 in Br J Oral Maxillofac Surg, 43(2): 166-8.
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