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Mesenchymal stem cells for bone repair: preclinical studies and potential orthopedic applications.

Arinzeh TL

New Jersey Institute of Technology Biomedical Engineering, 614 East Building, University Heights, Newark, NJ 07102, USA. arinzeh@njit.edu

Mesenchymal stem cells (MSCs), derived from adult bone marrow, are multi-potent stem cells capable of differentiating along several lineage pathways. From a small bone marrow aspirate, MSCs can be readily isolated and easily expanded. Therefore, MSCs are thought to be a readily available source of cells for many tissue engineering and regenerative medicine applications. This review covers preclinical models that evaluate the efficacy of MSC-loaded scaffolds in large bone defects as a potential substitute for autologous and allogeneic bone grafts. This review also covers new approaches to clinical use of MSC technology.

Published 21 November 2005 in Foot Ankle Clin, 10(4): 651-65, viii.
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